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Self-Emulsifying Drug Delivery System (SEDDS) and its Pharmaceutical Applications

[ Vol. 7 , Issue. 3 ]

Author(s):

Sankha Bhattacharya*   Pages 206 - 224 ( 19 )

Abstract:


Poor aqueous solubility, oral bioavailability, inter, and inter-subject variability, and physical stability have always been a concern for pharmaceutical formulation scientists while formulating an oral dosage form. Self-Emulsifying Drug Delivery System (SEDDS) is a promising new approach to mitigating those potential problems. The main advantages of SEDDS are that it increases the solubility and decreases the bio-degradation of lipophilic drugs. Mostly BCS II & IV Class drugs are preferable. SEDDS is an admixture of drugs, oil, surfactants, cosolvents, and stabilizers. With little energy input, they form (o/w) microemulsion within the G.I. lumen. The present review discusses the various formulations of SEDDS, selection criteria for surfactants, oils, Patentable SEDDS dosage forms, solidification technique, characterization, and future approaches.

Keywords:

Self-emulsified drug delivery system (SEDDS), aqueous solubility, self-micro emulsifying drug delivery system (SMEDDS), co-surfactant, solid self-emulsifying drug delivery system (S-SEDDS), patents of SEDDS.

Affiliation:

Department of Pharmaceutics, ISF College of Pharmacy, G.T. Road (NH-95), Ghal Kalan, Moga, Punjab 142001

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