Vishruti V. Kadam, Vrutti I. Patel, Manisha S. Karpe and Vilasrao J. Kadam Pages 44 - 55 ( 12 )
Background: Microsponges is a class of polymeric microspheres that are porous and are aimed to deliver a pharmaceutically active constituent competently at the smallest dose and also, to alter release of the drug.
Objective: The aim of the present work was to formulate a topical gel based drug delivery system of microsponges containing Celecoxib (CXB).
Method: Quasi emulsion solvent diffusion method was used to prepare microsponges. The inner phase of formulation (drug dissolved in polymer solution) was added drop-wise into outer phase of Polyvinyl Alcohol (PVA) solution at room temperature. Microsponges were obtained after stirring for 3 hours. Drug loaded microsponges, dispersed in propylene glycol, were added to soaked carbopol and mixed thoroughly. Final pH was adjusted by triethanolamine. Final formulation was evaluated for particle size, % entrapment efficiency, % production yield, surface morphology, % drug release, drug content, rheological behaviour, in vitro skin permeation etc.
Results: Microsponges of optimized batch were spherical, fine and free flowing. The optimized formulation showed % practical yield of 72.84 ± 1.34, % entrapment efficiency of 82.4 ± 1.48 and mean particle size of 26.4 m. The optimized batch incorporated in gel showed pH of 6.1, 12.35 grams-cm/sec of spreadability, 99.06 % of drug content and 68.1 % drug release. Skin permeation studies concluded that the drug was released in a controlled manner for a period of 12 hours. The optimized batch was found to be appropriately stable.
Conclusion: The CXB loaded in a microsponge based gel was found to have good appearance, other micromeritic properties and entrapment efficiency along with controlled in vitro release profile of drug.
Carbopol, celecoxib, microsponge based gel, quasi emulsion, solvent diffusion.
Bharati Vidyapeeth’s College of Pharmacy, Department of Pharmaceutics, C.B.D. Belapur, Sector 8, Navi Mumbai, India.